• V. D. Suryawanshi
• D.S.Kharate

Introduction: Fluoride is found naturally in soil, water, and food items. Fluoride has long been used as rodents and pesticides to kill mice and pests which is a very acute poisoning that is more toxic than lead and less toxic than arsenic. Fluoridation of water has been banned in many important countries such as France, Germany, Austria, Belgium, Denmark, and Greece. The presence of fluoride is found in water, foods, and crops. Fluoride in drinking water poses health problems when intake exceeds mg per liter, that is, the human body has the ability to tolerate fluoride content to a limit. The Bureau of Indian Standards and the World Health Organization set a maximum fluoride limit of 1.5 ppm (Li, 2003).The amount of fluoride in foods depends mainly on soil type, salts present in the soil, and available water. High fluoride-rich water increases the amount of fluoride in food and vegetables (Ortiz-PD et al., 2003). Fluorosis occurs when a person continues to practice soluble fluoride-rich drinking water more than the standard limit (Mohanty and Rao, 2010 ; Gao et al., 2014; Mahmoud et al., 2020; Dehghani et al., 2020; ). In addition to drinking water, fluoride enters the human body mainly through food, air, medicines, and cosmetics), Peckham et al. 2014). It has been observed that fluoride enters the human body through tea, fluoride-containing toothpaste, and highly soluble fluoride-containing drinking water. Fluoride also reaches our body through cold drinks ). It becomes even more difficult to estimate his mental instincts. When the amount of fluoride in ordinary drinking water is high, fluoride in the human body accumulates itself by removing hydroxide from the bones and gives rise to bone fluorosis (Dehghani et al., 2021Hedman et al., 2006Balzar Ekenback et al., 2001Marthaler and Petersen, 2005; Moss and Kumar 2021) and (Gao et al., 2014; Amini et al., 2016; Dehghani et al., 2019). It has been observed that fluorosis disease develops very quickly in uneducated, poor, and malnourished villagers (Dehghani et al., 2018Buzalaf and Whitford, 2011; Anbazhagan et al., 2019; ; Yousefi, Ghalehaskar et al., 2019). In the grip of fluorosis, a man starts to grow untimely, his waist starts tilting and he becomes helpless by walking (Dehghani et al., 2016Fawell et al., 2006; ). Fluoride is a neurotoxin, affecting mental develop¬ment all over the world, such as autism, atten¬tion deficit disorder, and other malformations and other similar industrial side products and the relationship between them is now clear. Its effects on health have caused serious concerns to mankind, including fatal diseases such as problems with bones, teeth, cancer, reproductive, gastrointestinal, endocrinological, and neurological devel¬opment. This fluoride is also the cause of intestinal ulcers, impotence in men, and infertility in women due to repeated miscarriages. For all these reasons, the body’s resistance to power decreases when drinking fluoride-containing water continuously (Sarkar and Pal, 2014Basha et al., 2011). It is well known that most toothpaste contains fluoride. Mouthwash is also a type of fluoride-containing water that absorbs fluoride in the bloodstream within minutes.

TOXICOLOGICAL EFFECTS OF FLUORIDE ON HUMAN HEALTH

"TOXICOLOGICAL EFFECTS OF FLUORIDE ON HUMAN HEALTH ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.8, Issue 12, page no.234-240, December-2021, Available :http://www.jetir.org/papers/JETIRFI06038.pdf

"TOXICOLOGICAL EFFECTS OF FLUORIDE ON HUMAN HEALTH ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.8, Issue 12, page no. pp234-240, December-2021, Available at : http://www.jetir.org/papers/JETIRFI06038.pdf