• Manisha Choudhary

Diabetes research has made significant use of animal models. Early research on the function of the pancreas in glucose homeostasis relied on pancreatectomized dogs, which led to the discovery and purification of insulin. Animal testing has become controversial in today's society, with varying levels of legal and ethical restraint. Rodents are the primary experimental subjects, although some research is done on bigger animals as well. Streptozotocin and alloxan, among other toxins, cause hyperglycemia in rats and mice. It has been shown that selective inbreeding has generated a number of animal strains that are good representations of the phenotypes associated with type 1 and type 2 diabetes (as well as other metabolic disorders). The majority of novel therapies for diabetes, such as islet cell transplantation and preventive measures like insulin injections, are first tested in animals before moving on to humans. Many novel diabetic animal models have been developed recently using molecular biology methods, such as knock-in, generalized knock-out, and tissue specific knock-out mice.

Diabetes, Mouse, Rat, Rodent, Transgenic.

"Diabetes Mellitus Animal Models", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 2, page no.261-265, February-2019, Available :http://www.jetir.org/papers/JETIRFJ06055.pdf

"Diabetes Mellitus Animal Models", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 2, page no. pp261-265, February-2019, Available at : http://www.jetir.org/papers/JETIRFJ06055.pdf