• Dr. Santosh Kumar Singh

To evaluate the transfer of 2-naphthol (2-NPH) in fullterm human placental tissues. Six placentas were examined. The ex-vivo dual closed-loop human placental cotyledon perfusion model was utilized. 2-NPH was introduced to the perfusate in the maternal compartment. Samples were obtained from the maternal and fetus up to 360 min measurement. The mean fetal weight was 2880 ± 304.2 g. Mean perfused cotyledon weight was 26.3 (±5.5) g. All unperfused placental tissue samples contained NPH with a mean level of 7.98 (±1.73) gg compared to a mean of 15.58 (±4.53) gg after 360 min perfusion. A fast decrease in maternal 2-NPH concentration swas found; from 5.54 gg in the first 15 min and 13.8 gg in 360 min. The fetal side rose from 0.65 gg in the first 15 min to 1.5 gg in 360 min. The transfer rate of NPH was significantly lower than that of antipyrine. 2-NPH has the capacity to quickly traverse the placenta from the maternal to the fetal compartment within 15 min. The placenta appears to have a function in restricting the flow of 2-NPH in the fetal compartment.

Human, 2-Naphthol, Placenta, Transfer.

"2-Naphthol Transplacental Transfer in Human Placenta: A Review", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 1, page no.372-377, January-2019, Available :http://www.jetir.org/papers/JETIRFT06072.pdf

"2-Naphthol Transplacental Transfer in Human Placenta: A Review", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 1, page no. pp372-377, January-2019, Available at : http://www.jetir.org/papers/JETIRFT06072.pdf