UGC Approved Journal no 63975(19)

ISSN: 2349-5162 | ESTD Year : 2014
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Published in:

Volume 10 Issue 4
April-2023
eISSN: 2349-5162

UGC and ISSN approved 7.95 impact factor UGC Approved Journal no 63975

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Published Paper ID:
JETIRFW06006


Registration ID:
512365

Page Number

47-55

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Title

Synthesis and antibacterial evaulation of Diamino-phenyl pyrimidine-carbonitrile derivatives using Iron Acetylacetonate as an efficient catalyst

Abstract

One-pot three component synthesis of 2,6-diamino-6-phenyl pyrimidine-5-carbonitrile derivatives by the condensation of substituted Aromatic aldehydes, malononitrile and guanidine hydro-chloride in ethanol using iron acetylacetonate Fe(acac)3 catalyst. Fe(acac)3 has been used as a catalyst in preparation, degradation, and calcification of biodegradable polyurethane foams for bone graft substitutes.The products have been assayed for their antimicrobial screening against Gram+ve and Gram-ve bacteria. Some of the products showed moderate activity when compared with known standard drug viz. penicillin at the same concentration 50μgm/ml. Spectroscopic tequeniques are very good tools for the identification of compounds. The structures have been confirmed by 1H NMR, 13C-NMR, IR, and Mass spectral data.

Key Words

Aromatic aldehydes, Malononitrile, Guanidine Hydrochloride, Iron Acetylacetonate, Antimicrobial screening.

Cite This Article

"Synthesis and antibacterial evaulation of Diamino-phenyl pyrimidine-carbonitrile derivatives using Iron Acetylacetonate as an efficient catalyst", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.10, Issue 4, page no.47-55, April-2023, Available :http://www.jetir.org/papers/JETIRFW06006.pdf

ISSN


2349-5162 | Impact Factor 7.95 Calculate by Google Scholar

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 7.95 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Cite This Article

"Synthesis and antibacterial evaulation of Diamino-phenyl pyrimidine-carbonitrile derivatives using Iron Acetylacetonate as an efficient catalyst", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.10, Issue 4, page no. pp47-55, April-2023, Available at : http://www.jetir.org/papers/JETIRFW06006.pdf

Publication Details

Published Paper ID: JETIRFW06006
Registration ID: 512365
Published In: Volume 10 | Issue 4 | Year April-2023
DOI (Digital Object Identifier):
Page No: 47-55
Country: -, -, India .
Area: Engineering
ISSN Number: 2349-5162
Publisher: IJ Publication


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