UGC Approved Journal no 63975(19)

ISSN: 2349-5162 | ESTD Year : 2014
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Published in:

Volume 10 Issue 4
April-2023
eISSN: 2349-5162

UGC and ISSN approved 7.95 impact factor UGC Approved Journal no 63975

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Published Paper ID:
JETIRFW06014


Registration ID:
512355

Page Number

116-126

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Title

FORMULATION AND EVALUATION OF NANOSPONGE TABLET

Abstract

The aim of the present study is development and characterization of silymarin nanosponges and its tablet formulation targeted for Liver cirrhosis. Nanosponge is a modern category of material and is composed of minute particles with small, nanometer-wide cavities. Different kinds of materials can be used to fill these little cavities. These tiny particles have the potential to transport both hydrophilic and lipophilic drug substances, which can boost the stability of molecules or drugs that are poorly water soluble and also bioavailability. Utilizing a methodical quality by Design approach, silymarin-loaded nanosponge were produced and optimized, first, the Critical quality attributes (CQAs) and Critical material attributes (CMAs) of the nanosponge formulation were determined (CMAs). The present work aimed to design and optimize nanosponge with higher drug entrapped efficiency, Drug content and better stability. The formulation was optimized by 3 factor 3 level Box-Bechken design using Polymer concentration(X1), Stirring time(X2) and Stirring rate(X3) as independent variable (CMAs). Particle size (Y1). Entrapment efficiency (Y2), Percentage practical yield (Y3) and Drug content (Y4) was evaluated as dependent variables. Optimized formulation was then evaluated for FTIR, DSC, XRD, Particle size analysis, Zeta potential, SEM. Formulation was also found stable at different storage condition as dependent CQAs. Optimized formulation was then evaluated for FTIR, Particle size analysis, Zeta potential, SEM & Hepatoprotective activity

Key Words

Liver cirrhosis, Silymarin, Nanosponge, QbD, Box Behnken Design.

Cite This Article

"FORMULATION AND EVALUATION OF NANOSPONGE TABLET ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.10, Issue 4, page no.116-126, April-2023, Available :http://www.jetir.org/papers/JETIRFW06014.pdf

ISSN


2349-5162 | Impact Factor 7.95 Calculate by Google Scholar

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 7.95 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Cite This Article

"FORMULATION AND EVALUATION OF NANOSPONGE TABLET ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.10, Issue 4, page no. pp116-126, April-2023, Available at : http://www.jetir.org/papers/JETIRFW06014.pdf

Publication Details

Published Paper ID: JETIRFW06014
Registration ID: 512355
Published In: Volume 10 | Issue 4 | Year April-2023
DOI (Digital Object Identifier):
Page No: 116-126
Country: -, -, India .
Area: Engineering
ISSN Number: 2349-5162
Publisher: IJ Publication


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