• Madhav M. Kendre
• Ravi Ramlu Vidule

Flavanoids are important biosynthetic precursors for the synthesis of flavones, isoflavones, flavonols, flavonone and 3-chloroflavone. The 3-chloroflavone skeleton is present in a wide range of synthetic and naturally occurring products exhibiting various interesting pharmacological activities. In the present investigation, a series of some 3-Chloro-2-(4′-dimethylamino-phenyl)-4H-chromen-4-ones,(2a-j) have been synthesized by oxidative cyclization of 1-(substituted-2-hydroxy-phenyl)-3-(4′-dimethylamino-phenyl)-prop-2-en-1-ones (2-hydroxychalcones) (1a-j) with CuCl2 using DMSO as a solvents with good yield of 3-Chloroflavone (72%). The products were tested for purity by TLC and structures of synthesized compounds were confirmed by IR, 1H NMR and Mass spectral analysis. All these synthesized compounds were evaluated for their antimicrobial activity.

2-hydroxychalcone, 3-Chloroflavone, Antimicrobial Activities

"SYNTHESIS, CHARACTERIZATIONS AND ANTIMICROBIAL ACTIVITY OF SOME 3-CHLOROFLAVONE DERIVATIVES", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.10, Issue 4, page no.448-454, April-2023, Available :http://www.jetir.org/papers/JETIRFW06059.pdf

"SYNTHESIS, CHARACTERIZATIONS AND ANTIMICROBIAL ACTIVITY OF SOME 3-CHLOROFLAVONE DERIVATIVES", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.10, Issue 4, page no. pp448-454, April-2023, Available at : http://www.jetir.org/papers/JETIRFW06059.pdf