UGC Approved Journal no 63975(19)

ISSN: 2349-5162 | ESTD Year : 2014
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Published in:

Volume 10 Issue 4
April-2023
eISSN: 2349-5162

UGC and ISSN approved 7.95 impact factor UGC Approved Journal no 63975

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Published Paper ID:
JETIRFW06059


Registration ID:
512299

Page Number

448-454

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Title

SYNTHESIS, CHARACTERIZATIONS AND ANTIMICROBIAL ACTIVITY OF SOME 3-CHLOROFLAVONE DERIVATIVES

Abstract

Flavanoids are important biosynthetic precursors for the synthesis of flavones, isoflavones, flavonols, flavonone and 3-chloroflavone. The 3-chloroflavone skeleton is present in a wide range of synthetic and naturally occurring products exhibiting various interesting pharmacological activities. In the present investigation, a series of some 3-Chloro-2-(4′-dimethylamino-phenyl)-4H-chromen-4-ones,(2a-j) have been synthesized by oxidative cyclization of 1-(substituted-2-hydroxy-phenyl)-3-(4′-dimethylamino-phenyl)-prop-2-en-1-ones (2-hydroxychalcones) (1a-j) with CuCl2 using DMSO as a solvents with good yield of 3-Chloroflavone (72%). The products were tested for purity by TLC and structures of synthesized compounds were confirmed by IR, 1H NMR and Mass spectral analysis. All these synthesized compounds were evaluated for their antimicrobial activity.

Key Words

2-hydroxychalcone, 3-Chloroflavone, Antimicrobial Activities

Cite This Article

"SYNTHESIS, CHARACTERIZATIONS AND ANTIMICROBIAL ACTIVITY OF SOME 3-CHLOROFLAVONE DERIVATIVES", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.10, Issue 4, page no.448-454, April-2023, Available :http://www.jetir.org/papers/JETIRFW06059.pdf

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2349-5162 | Impact Factor 7.95 Calculate by Google Scholar

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 7.95 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Cite This Article

"SYNTHESIS, CHARACTERIZATIONS AND ANTIMICROBIAL ACTIVITY OF SOME 3-CHLOROFLAVONE DERIVATIVES", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.10, Issue 4, page no. pp448-454, April-2023, Available at : http://www.jetir.org/papers/JETIRFW06059.pdf

Publication Details

Published Paper ID: JETIRFW06059
Registration ID: 512299
Published In: Volume 10 | Issue 4 | Year April-2023
DOI (Digital Object Identifier):
Page No: 448-454
Country: -, -, India .
Area: Engineering
ISSN Number: 2349-5162
Publisher: IJ Publication


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