• Gauri M. Paratkar
• Sachin Hangargekar
• Pradip Landge

The objective of the study was to develop floating in situ gel formulations. These formulations increase the targeted action on bacteria for a longer time that can be used in the treatment of various gastric diseases. Floating drug delivery system comes with the advantage of sustained release of drugs over a prolonged period of time thereby maximizing the oral absorption of drugs with narrow absorption window, it overcomes the challenges of conventional oral drug delivery system. In situ gel formulations were prepared by varying concentrations of sodium alginate as in situ gel forming bio-degradable polymer and calcium carbonate as a cross-linking agent. The formulations were evaluated for Physical appearance, pH, in vitro drug release, viscosity, in vitro floating behaviour, in vitro gelling capacity and drug content.

in-situ gel, Floating drug delivery system, drug delivery systems, sol to gel form.

"GENERAL REVIEW ON FORMULATION AND EVALUATION OF NOVEL FLOATING IN SITU GEL FOR GASTRORETENTIVE DRUG DELIVERY", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.10, Issue 4, page no.483-488, April-2023, Available :http://www.jetir.org/papers/JETIRFW06065.pdf

"GENERAL REVIEW ON FORMULATION AND EVALUATION OF NOVEL FLOATING IN SITU GEL FOR GASTRORETENTIVE DRUG DELIVERY", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.10, Issue 4, page no. pp483-488, April-2023, Available at : http://www.jetir.org/papers/JETIRFW06065.pdf