• Jadhav S
• Gosar A,
• Mandawad G
• Patil S
• Hote B,Hallale s,Jadkar A.

This article mainly reports the Inductive effect on Rasagiline Mesylate drug substance by FTIR Spectroscopy. The Inductive effect is a temporary effect that produced a partial shifting of σ electrons towards a more electronegative atom of σ bond. This means σ (or single-bond electrons) shifts towards a more electronegative atom. Because of this, partial charges develop, the OH group from the water molecule attacking to the carbon carbon triple bond to form carbon double bond and the molecule gets Partial charge developed and it is a temporary effect, so once the water is removed, the partial charge removed and molecule goes back to its original state. Due to this, here there is no shifting of the Carbon carbon triple bond to the carbon carbon double bond take place and resulting in The IR spectra showing two vibration frequencies in the region of 3219.20 cm.-1 and 3278.99 cm.-1 Sample treated with a mixture of Ethyl acetate and Isopropyl alcohol, followed by drying at 105°C does not involve in the Inductive effect. And IR spectra show one vibration frequency at 3278.99cm-1 and there is no shifting of carbon carbon triple bond to carbon carbon double bond take place and does not involve the Inductive effect.

Inductive Effect, Hygroscopic, FTIR spectroscopy, Rasagiline Mesylate.

"The Hydrogen bond in Rasagiline Mesylate drug substance interaction with moisture studies by FTIR, XRD, and TGA", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.10, Issue 4, page no.646-649, April-2023, Available :http://www.jetir.org/papers/JETIRFW06086.pdf

"The Hydrogen bond in Rasagiline Mesylate drug substance interaction with moisture studies by FTIR, XRD, and TGA", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.10, Issue 4, page no. pp646-649, April-2023, Available at : http://www.jetir.org/papers/JETIRFW06086.pdf