UGC Approved Journal no 63975(19)

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Published in:

Volume 9 Issue 11
November-2022
eISSN: 2349-5162

UGC and ISSN approved 7.95 impact factor UGC Approved Journal no 63975

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Published Paper ID:
JETIRTHE2020


Registration ID:
504408

Page Number

b265-b299

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Title

Solubility Enhancement of selected statins using different approaches.

Abstract

The main aim of the present research work was to improve bioavailability of Rosuvastatin calcium by preparing solid dispersion, solid lipid nano particles, and nono particles. These were prepared using different concentration surfactants, carrier and stabilizer by solvent evaporation method. The prepared formulation of solid dispersion, nano particles and solid lipid nano particles were evaluated for material balance, compatability studies, solubility, surface morphology, entrapment efficiency, drug content, zeta potential, in-vitro release profile, kenitic data analysis and stability studies For solid dispersion nine total formulation were prepared DF1-DF9 among these DF7 was found to be better because it has solubility of 0.41±0.02, entrapment efficiency 68.95% and drug release was found to be 89.98±0.28%. For solid lipid nano particles six total formulations were prepared (SF1-SF6) among these SF6 were found to be better because it has solubility of 0.56±0.01, entrapment efficiency 49.24% and drug release was found to be 93.54±0.92%. For nano particles eight total formulations were prepared (NF1-NF8) among these NF4 was found to be better because it has solubility of 0.37±0.25, entrapment efficiency 57.12% and drug release was found to be 91.23±0.05%. Selected formulation DF7, SF6, and NF4 were used for stability studies. Stability data reveals that the preparation are found to be stable with negligible in content, solubility, dissolution etc. Among the different techniques of solubility enhancement NF4 was found to be best formulation.

Key Words

Rosuvastatin calcium, solid dispersion, solid lipid nanoparticles and nanoparticles. Solvent evaporation , solubility, drug entrapment and in-vitro studies.

Cite This Article

"Solubility Enhancement of selected statins using different approaches.", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.9, Issue 11, page no.b265-b299, November-2022, Available :http://www.jetir.org/papers/JETIRTHE2020.pdf

ISSN


2349-5162 | Impact Factor 7.95 Calculate by Google Scholar

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 7.95 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Cite This Article

"Solubility Enhancement of selected statins using different approaches.", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.9, Issue 11, page no. ppb265-b299, November-2022, Available at : http://www.jetir.org/papers/JETIRTHE2020.pdf

Publication Details

Published Paper ID: JETIRTHE2020
Registration ID: 504408
Published In: Volume 9 | Issue 11 | Year November-2022
DOI (Digital Object Identifier):
Page No: b265-b299
Country: Belgaum , Karnataka, India .
Area: Pharmacy
ISSN Number: 2349-5162
Publisher: IJ Publication


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