• Anurag Kumar Gupta
• Mohini Rawat
• Dr. Praveen Kumar Chaudhary

Transdermal patches were developed to facilitate drug delivery in conditions where other routes are impractical or challenging to achieve the desired drug concentration. This study was focused on the development of Amlodipine Besylate Transdermal Patch by using matrix-type solvent casting method. The formulation was developed by incorporating various ingredients such as HPMC as the polymer, PEG 200 as the plasticizer, Olive oil, and Eugenol as permeation enhancers. Ethanol was used to dissolve the drug prior to loading, as it is volatile and easily evaporates (Dipen Patel, 2012). Minitab software was utilized to design the formulations, resulting in a total of 13 patches, including dummy patches optimized based on folding endurance and thickness. Each patch underwent various characterizations, including thickness measurement, folding endurance assessment, weight variation analysis, release evaluation, and permeation testing. Among the formulations, F2 exhibited the highest thickness, ranging from 1.142 mm to 1.438 mm. Notably, despite the consistent concentration of plasticizer in each formulation, the folding endurance varied significantly, ranging from 6 to 207. The weight variation of the patches was observed to be within the range of 0.0866 to 1.43 gm. Formulation F2 had the highest weight due to its elevated amount of penetration enhancer. The cumulative drug release over 8 hours varied between 10.46% and 39.95% across different patches, with Formulation F8 demonstrating the highest drug release. However, the drug permeation rate was relatively low compared to the drug release, with a cumulative percentage of drug permeation observed at only 4.52%.

Amlodipine Besylate, HPMC, Matrix Type, Solvent casting method, Olive Oil, Eugenol, Permeation enhancer

"FORMULATION AND EVALUATION OF TRANSDERMAL DRUG DELIVERY OF AMLODIPINE BESYLATE", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.10, Issue 9, page no.d304-d342, September-2023, Available :http://www.jetir.org/papers/JETIRTHE2067.pdf

"FORMULATION AND EVALUATION OF TRANSDERMAL DRUG DELIVERY OF AMLODIPINE BESYLATE", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.10, Issue 9, page no. ppd304-d342, September-2023, Available at : http://www.jetir.org/papers/JETIRTHE2067.pdf