• Md Aslam

Using several hydrophilic polymers (HPMC, Carbopol, and Thickener), the goal of this study was to design and develop an absurdly long-acting levosulpride formulation. To produce the levosulpride vehicle profile, a range of excipient dosages (25, 50, and 75 mg) were utilized. We used in vitro debilitating ponders to assess the medication's development imperativeness, and the definitions were coordinated using ignite strain methodology. L4, out of all the subtleties tested, demonstrated the most remarkable vehicle properties, with a drug release of 99.41% over 12 hours. The polymer blends' sensitivity in regulating drug release is hinted at by the extensive development profile, which also suggests possibilities for redesigned figuring out consistency and chipped missing at obliging outcomes. The purpose of these disclosures is to enable additional pharmacokinetic considerations to support clinical sufficiency and to outline the limitations of employing HPMC, Carbopol, and Thickener in the strategy for levosulpride extended release structures.

Levosulpride, High-Pressure Sodium Carbopol, and Thickener

"FORMULATION AND IN VITRO EVALUATION OF EXTENDED RELEASE OF LEVOSULPRIDE", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.11, Issue 12, page no.i1-i40, December-2024, Available :http://www.jetir.org/papers/JETIRTHE2167.pdf

"FORMULATION AND IN VITRO EVALUATION OF EXTENDED RELEASE OF LEVOSULPRIDE", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.11, Issue 12, page no. ppi1-i40, December-2024, Available at : http://www.jetir.org/papers/JETIRTHE2167.pdf