• piyush pankaj vishwakarma
• Ravindra Mishra

The purpose of this study is to develop and characterize a successful colloidal nano-carrier viz. microemulsion for oral delivery as well as for topical delivery of antigout drug. Gout is a metabolic disorder which causes inflammation of the joints hence the pain. It is the most common crystal arthropathy and induced by the deposition of monosodium urate (MSU) crystal in joint and soft tissues that can produce an acute or chronic arthritis or inflammatory arthritis. The present study will conduct to investigate the microemulsion based drug delivery system of antigout drug febuxostat( FBT) in order to bypass its gastrointestinal adverse effect and to improve patient compliance and hence improve therapeutic efficacy.. Microemulsion will develop and optimize using box behnken design i.e. by using design expert software. The develop microemulsion based gels will characterized for pH, spreadability , drug content, viscosity and transdermal permeability of drug. Optimized gel formulation will then subject to in vitro antigout study in comparison to marketed available formulation of Febuxostat by using monosodium urate (MSU) crystals induced animal model.

Keywords:Febuxostat, microemulsion, microemulsion based gel, antigout, transdermal permeability and topical delivery

"Preparation and evaluation of buccoadhesive gel containing optimized Febuxostat-loaded microemulsion", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 6, page no.1961-1972, June-2019, Available :http://www.jetir.org/papers/JETIR2006284.pdf

"Preparation and evaluation of buccoadhesive gel containing optimized Febuxostat-loaded microemulsion", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 6, page no. pp1961-1972, June-2019, Available at : http://www.jetir.org/papers/JETIR2006284.pdf