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Published in:

Volume 7 Issue 6
June-2020
eISSN: 2349-5162

Unique Identifier

JETIR2006429

Page Number

626-638

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Title

METHOD DEVELOPMENT, VALIDATION OF STABILITY INDICATING LIQUID CHROMATOGRAPHIC METHOD AND FORCE DEGRADATION STUDY OF PYRIMIDINE DERIVATIVE

ISSN

2349-5162

Cite This Article

"METHOD DEVELOPMENT, VALIDATION OF STABILITY INDICATING LIQUID CHROMATOGRAPHIC METHOD AND FORCE DEGRADATION STUDY OF PYRIMIDINE DERIVATIVE", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.7, Issue 6, page no.626-638, June-2020, Available :http://www.jetir.org/papers/JETIR2006429.pdf

Abstract

An isocratic reversed phase stability-indicating high-performance liquid chromatographic (HPLC) assay method was developed and validated for quantitative determination of pyrimidine derivative and the simultaneous stability indicating study was carried out by using gradient pump system with the mobile phase Methanol/ Water (55/45) was selected to achieve maximum detection. SHIMADZU-HPLC, phenomenex C18, 250×4.6mm, 5µ column was used for the detection having flow rate 1ml/min, at 225 nm. The proposed method was found to be rapid, accurate and robust.

Key Words

HPLC method development, Stability indicating method, Pyrimidine Derivative.

Cite This Article

"METHOD DEVELOPMENT, VALIDATION OF STABILITY INDICATING LIQUID CHROMATOGRAPHIC METHOD AND FORCE DEGRADATION STUDY OF PYRIMIDINE DERIVATIVE", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.7, Issue 6, page no. pp626-638, June-2020, Available at : http://www.jetir.org/papers/JETIR2006429.pdf

Publication Details

Published Paper ID: JETIR2006429
Registration ID: 234625
Published In: Volume 7 | Issue 6 | Year June-2020
DOI (Digital Object Identifier):
Page No: 626-638
ISSN Number: 2349-5162

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Cite This Article

"METHOD DEVELOPMENT, VALIDATION OF STABILITY INDICATING LIQUID CHROMATOGRAPHIC METHOD AND FORCE DEGRADATION STUDY OF PYRIMIDINE DERIVATIVE", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.7, Issue 6, page no. pp626-638, June-2020, Available at : http://www.jetir.org/papers/JETIR2006429.pdf




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