• JITENDRA KUMAR YADAV

Xanthenes’ derivative is nitrogen containing heterocyclic aromatic compounds. Various heterocyclic compounds have show stimulation of cardiac muscle, enhanced dieresis, stimulation of CNS and finally a soothing relaxation of Bronchi and the coronary arteries. Literatures in the recent past reveal that some theophylline derivative possesses antibacterial and enhance Antitussive and Bronchodilator activity. The synthesis of substituted 1,3-Dimethylxanthine derivative consist of the following steps which are as follows. Step-I: Synthesis of the 7-(undec-10-ene)theophylline Step-II: Synthesis of the 8-(7-Chloroquinoline)-7-(undec-10-ene)theophylline Step-III: Synthesis of 7-(7-Chloroquinoline)theophylline All the synthesized compounds by the above described method result in products with good yields. IR, 1H NMR and Mass spectroscopic analysis conformed the structures of new synthesized compounds. The newly synthesized compounds were screened for their Bronchodilator activities by using Theophylline as standard and are found to be effective Bronchodilator agent.

Synthesis of the 8-(7-Chloroquinoline)-7-(undec-10-ene)theophylline

"“SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL ACTIVITY EVALUATION OF 4-AMINOQUNOLINE 1, 2, 4-TRIAZOLE DERIVATVES”", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.10, Issue 8, page no.d552-d587, August-2023, Available :http://www.jetir.org/papers/JETIRTHE2055.pdf

"“SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL ACTIVITY EVALUATION OF 4-AMINOQUNOLINE 1, 2, 4-TRIAZOLE DERIVATVES”", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.10, Issue 8, page no. ppd552-d587, August-2023, Available at : http://www.jetir.org/papers/JETIRTHE2055.pdf