• SEEMA R SHEJWAL
• DR. GAJANAN S. SANAP
• SHAIKH MOHAMMED ABRAR
• SHAIKH MEHMOOD DAWOOD
• VIJAY K .PATIL

Abstract : The present study aims to formulate mucoadhesive buccal drug delivery system of Diltiazem Hydrochloride, in view to improve the bioavailability of drug; which undergoes extensive hepatic first-pass metabolism, leading to increased dose and side effects. The concentration of polymers like HPMC-E-5, PVA, and plasticizers like Glycerin, Dibutyl-phthalate, and solvents was optimized through preliminary study. Depending upon the results of Trial Batches, the concentration of polymers and plasticizers was optimized. The results were analyzed. The optimized formulation batch was found to be D4D, containing diltiazem hydrochloride 30mg, PVA 250mg, DBP 5%, and D/W 2ml and Acetone 8ml. The stability study of D4D formulation revealed that formulation was stable.

Diltiazem hydrochloride, buccal delivery, buccal patches.

"FORMULATION AND EVALUATION OF MUCCOADHESIVE BUCCAL PATCH CONTAINING DILTIAZEM HYDROCHLORIDE", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 6, page no.890-896, June 2019, Available :http://www.jetir.org/papers/JETIR1907C84.pdf

"FORMULATION AND EVALUATION OF MUCCOADHESIVE BUCCAL PATCH CONTAINING DILTIAZEM HYDROCHLORIDE", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 6, page no. pp890-896, June 2019, Available at : http://www.jetir.org/papers/JETIR1907C84.pdf