• Ms. Sonal S. Fande
• Mrs. Deepali S. Ghorpade

An accurate, simple, precise, rapid and robust RP-HPLC method has been developed for estimation of bosutinib in bulk and pharmaceutical dosage form. The separation was achieved on C18 column (250 mm×4.6mm, 5µm), using Acetonitrile: Methanol: water (80:5:15) as a mobile phase, at flow rate 1.0 ml/min. Detection was carried out at 246 nm and drug eluted with a retention time were 5.63 min. Beer’s law was obeyed with the concentration range of 20-100µg/ml with correlation coefficient 0.999. The method has been validated according to ICH guidelines for linearity, accuracy, precision, robustness, range, LOD and LOQ. The method was found to be accurate, simple, precise, robust and rapid. The proposed method was convenient for quantitative routine analysis and quality control of bosutinib in bulk and pharmaceutical dosage form.

bosutinib, RP-HPLC, Validation

"METHOD DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR ESTIMATION OF BOSUTINIB IN BULK AND PHARMACEUTICAL DOSAGE FORM", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 6, page no.419-428, June 2019, Available :http://www.jetir.org/papers/JETIR1908065.pdf

"METHOD DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR ESTIMATION OF BOSUTINIB IN BULK AND PHARMACEUTICAL DOSAGE FORM", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 6, page no. pp419-428, June 2019, Available at : http://www.jetir.org/papers/JETIR1908065.pdf