UGC Approved Journal no 63975

ISSN: 2349-5162 | ESTD Year : 2014
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Published in:

Volume 6 Issue 6
June-2019
eISSN: 2349-5162

UGC and ISSN approved 7.95 impact factor UGC Approved Journal no 63975

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Published Paper ID:
JETIR1908C91


Registration ID:
302812

Page Number

704-727

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Title

FORMULATION AND EVALUATION OF FLOATING MICROCAPSULES OF ZOLPIDEM TARTARATE

Abstract

The hydro dynamically balanced modified release dosage form of ZOPLIDEM TARTARATE was targeted to be developed using a unique microcapsules platform..Microcapsules were formulated using Ethyl cellulose 7 cps as the controlled release polymer, HPMC 5 cps as the pore former and DCM and IPA as solvents for the drug and polymers. Water with 1% Tween 80 was used as the continuous phase. The formulation was optimized by using statistically designed 23 Design of experiments. The particle size, particle yield, drug content, entrapment efficiency, buoyancy studies and in vitro dissolution profile were the measurable parameters.The formulation showed that the particle size distribution, batch yield, drug content, entrapment efficiency, buoyancy studies were not the dependent variable. There were no significant differences in any of the above parameters in all the 8 experimental runs. However, in case of the in-vitro dissolution studies, the rate and extent of the release profile was strongly dependent on the drug and polymer ratio as well as on the pore forming concentration.[1,2]. A design space was defined within which an optimum formulation could be successfully achieved with the in- vitro release profile matching to the Target product profile.[3]

Key Words

Zolpidem tartarate, Floating microcapsules, HPMC, Ethyl cellulose, DOE

Cite This Article

"FORMULATION AND EVALUATION OF FLOATING MICROCAPSULES OF ZOLPIDEM TARTARATE", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 6, page no.704-727, June-2019, Available :http://www.jetir.org/papers/JETIR1908C91.pdf

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2349-5162 | Impact Factor 7.95 Calculate by Google Scholar

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 7.95 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Cite This Article

"FORMULATION AND EVALUATION OF FLOATING MICROCAPSULES OF ZOLPIDEM TARTARATE", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 6, page no. pp704-727, June-2019, Available at : http://www.jetir.org/papers/JETIR1908C91.pdf

Publication Details

Published Paper ID: JETIR1908C91
Registration ID: 302812
Published In: Volume 6 | Issue 6 | Year June-2019
DOI (Digital Object Identifier):
Page No: 704-727
Country: -, -, - .
Area: Engineering
ISSN Number: 2349-5162


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