• Sachin. S.Patil
• Dr.Gautam Saxena
• Dr T.S.Bharadwaj
• Dr. Vinay Rao

The hydro dynamically balanced modified release dosage form of ZOPLIDEM TARTARATE was targeted to be developed using a unique microcapsules platform..Microcapsules were formulated using Ethyl cellulose 7 cps as the controlled release polymer, HPMC 5 cps as the pore former and DCM and IPA as solvents for the drug and polymers. Water with 1% Tween 80 was used as the continuous phase. The formulation was optimized by using statistically designed 23 Design of experiments. The particle size, particle yield, drug content, entrapment efficiency, buoyancy studies and in vitro dissolution profile were the measurable parameters.The formulation showed that the particle size distribution, batch yield, drug content, entrapment efficiency, buoyancy studies were not the dependent variable. There were no significant differences in any of the above parameters in all the 8 experimental runs. However, in case of the in-vitro dissolution studies, the rate and extent of the release profile was strongly dependent on the drug and polymer ratio as well as on the pore forming concentration.[1,2]. A design space was defined within which an optimum formulation could be successfully achieved with the in- vitro release profile matching to the Target product profile.[3]

Zolpidem tartarate, Floating microcapsules, HPMC, Ethyl cellulose, DOE

"FORMULATION AND EVALUATION OF FLOATING MICROCAPSULES OF ZOLPIDEM TARTARATE", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 6, page no.704-727, June-2019, Available :http://www.jetir.org/papers/JETIR1908C91.pdf

"FORMULATION AND EVALUATION OF FLOATING MICROCAPSULES OF ZOLPIDEM TARTARATE", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 6, page no. pp704-727, June-2019, Available at : http://www.jetir.org/papers/JETIR1908C91.pdf