• Mr. Anurag Sharma
• Dr. Abhay Gupta

The purpose of this study was to develop and evaluate the effectiveness of novel in-situ gelling drug delivery systems that might be used for controlled administration of medication. The medicine that was tested in this study was called nizatidine. The effectiveness of in situ gels fabricated from a variety of environmentally sensitive polymers was evaluated using both in vitro and in vivo testing methodologies. The research was comprised of four distinct investigations, and we gathered the most significant data from each of those studies. "In situ gelling polymers" is another term for a reaction that is driven by an external stimulus. This phrase relates more specifically to formulations that gel upon contact with mucosa. "In situ gelling polymers" Since these formulations are fluid-like before they come into contact with the human surface, the primary advantage that they offer is that they may be easily supplied as a drop, an injection, or a spray device. This makes it possible to administer the medication in a variety of ways.

pH (potency of hydrogen), Nizatidine

"OPTIMIZATION FORMULATION AND EVALUATION OF IN-SITU GEL OF SOME ANTIULCER DRUG", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.10, Issue 2, page no.f635-f654, February-2023, Available :http://www.jetir.org/papers/JETIR2302572.pdf

"OPTIMIZATION FORMULATION AND EVALUATION OF IN-SITU GEL OF SOME ANTIULCER DRUG", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.10, Issue 2, page no. ppf635-f654, February-2023, Available at : http://www.jetir.org/papers/JETIR2302572.pdf