• Muhammad Zishan
• Aslam
• Zubair Alam
• Dr. Anjana Sharma

Nephrotoxicity is one of the most commonly reported kidney problems and occurs when the body consumes a chemical or medication. Medication may be an NSAID, a chemotherapeutic agent, or an antibiotic. The adverse effect of a drug or another chemical on renal function is referred to as "nephrotoxicity." This explorative article was undertaken to provide a holistic review of known nephroprotective (NP) phytoconstituents along with their research-based evidence and mechanism. The present review aimed to provide in-depth and better evidence of the global burden of nephrotoxicity, pathophysiology of nephrotoxicity, nephroprotective plants, and their phytoconstituents. By classifying and discussing the literature, we obtained many phytoconstituents, which were derived from herbal medicinal plants, from different origins. The mechanism of nephrotoxicity by several methods was proposed through discussing the literature. The occurrence and progression of Nephrotoxicity or AKI could be prevented by natural antioxidants through several pathways to prevent ROS accumulation and reduce renal cell injuries caused by excessive ROS formation. The plants that have – flavonoids, flavone, alkaloids, triterpenoids, glycosides, saponin, Gallic acid, β-Sitosterol, vitamin C, vitamin E, etc. show anti-oxidant and nephroprotective properties.

Nephrotoxicity, Nephroprotective plants, Cisplatin, In silico.

"A REVIEW ON INSIGHTS OF HERBAL NEPHROPROTECTIVE AGENTS. ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.11, Issue 2, page no.c844-c863, February-2024, Available :http://www.jetir.org/papers/JETIR2402298.pdf

"A REVIEW ON INSIGHTS OF HERBAL NEPHROPROTECTIVE AGENTS. ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.11, Issue 2, page no. ppc844-c863, February-2024, Available at : http://www.jetir.org/papers/JETIR2402298.pdf