• Radmehr Heidari Riseh
• Parham Arab zadeh
• Seyedeh Assal Tabatabaei Azad
• Amir-Reza Javanmard

Gliomas the most frequent type among primary brain tumors are highly heterogeneous. Developing successful therapies to overcome glioma requires a comprehensive knowledge of its molecular mechanisms. Several altered signaling pathways and cross-linked relationships of ncRNAs and coding RNAs remain to be investigated. Evidence demonstrates that ceRNA networks play a critical role in cellular processes, and dysregulation of any component of these networks could result in pathogenesis. Thus, identifying unknown interconnections between these genes may provide valuable clues for developing strategies for cancer therapy. In the present study, we aimed to identify potential regulatory networks involved in tumorigenesis of glioma, based on the ceRNA hypothesis. We used integrated bioinformatics analysis to construct a regulatory network associated with glioma tumorigenesis we acquired five axes, "CRNDE/has-mir-223/STAB1", "CRNDE1/has-mir-150/TOP2", "NEAT1/has-mir-150/TOP2", "GRM3-AS1/has-mir-128/TOP2" and "GRM3-AS1/has-mir-128/STAB1" as potential ceRNA regulatory networks in glioma patients.

LncRNAs, microRNAs, mRNAs, Bioinformatics

" Novel lncRNA‐miRNA‐mRNA competing endogenous RNA regulatory networks in glioma", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.11, Issue 3, page no.c283-c293, March-2024, Available :http://www.jetir.org/papers/JETIR2403236.pdf

" Novel lncRNA‐miRNA‐mRNA competing endogenous RNA regulatory networks in glioma", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.11, Issue 3, page no. ppc283-c293, March-2024, Available at : http://www.jetir.org/papers/JETIR2403236.pdf