• Deblina Halder
• Soumen Dey
• Suman Dan

Cancer treatment has changed as a result of the creation of intelligent and stimuli-responsive drug delivery systems, which allow for precise, regulated, and site-specific medication release while reducing systemic toxicity. These sophisticated systems can react to external stimuli like light, temperature, ultrasound, and magnetic fields, or to intrinsic tumour cues like pH, redox potential, enzyme activity, and hypoxia. Stimuli-responsive platforms use these triggers to improve treatment efficacy, overcome obstacles such tumour heterogeneity and multidrug resistance, and establish spatiotemporal control over drug release. Recent developments combine several cues, enabling on-demand therapeutic action and dynamic adaptation to intricate tumour microenvironments. Additionally, the integration of these platforms with biosensors and imaging agents has opened the door for theranostic systems that can monitor treatment and diagnose patients at the same time. Barriers pertaining to clinical translation, manufacturing scalability, and biological compatibility still exist despite tremendous advancements. With an emphasis on current developments and new trends, this review critically analyses the design concepts, workings, and therapeutic results of intelligent stimuli-responsive drug delivery systems. It also looks at potential future paths that could redefine precision oncology and enhance patient outcomes, such as programmable and customised delivery platforms.

Stimuli-responsive drug delivery, Controlled release, Tumor microenvironment, Theranostics, Precision oncology, Nanomedicine

"SMART AND STIMULI-RESPONSIVE PLATFORMS FOR CONTROLLED ANTICANCER DRUG RELEASE: DESIGN PRINCIPLES, THERAPEUTIC OUTCOMES, AND FUTURE DIRECTIONS", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.12, Issue 10, page no.d553-d557, October-2025, Available :http://www.jetir.org/papers/JETIR2510373.pdf

"SMART AND STIMULI-RESPONSIVE PLATFORMS FOR CONTROLLED ANTICANCER DRUG RELEASE: DESIGN PRINCIPLES, THERAPEUTIC OUTCOMES, AND FUTURE DIRECTIONS", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.12, Issue 10, page no. ppd553-d557, October-2025, Available at : http://www.jetir.org/papers/JETIR2510373.pdf