• Ms.pranali Vijay chavan
• Mrs.Snehal Dhananjay jadhav
• Pranjali Uttamgir Gosavi

Liver cirrhosis is a chronic, progressive liver disease due to the replacement of normal liver architecture with regenerative nodules and widespread hepatic fibrosis, which eventually results in liver failure. It is caused by chronic hepatic inflammation secondary to viral hepatitis, alcohol use-related liver disease, metabolic derangement, autoimmune disease, or drug-induced liver injury. Cirrhosis comes in two phases: compensated and decompensated, the latter with complications of ascites, variceal hemorrhage, hepatic encephalopathy, and hepatorenal syndrome. Cirrhosis is still a major health issue worldwide and remains a cause of high morbidity and mortality rates despite improvement in antiviral therapy, better diagnostics, and transplantation. Early detection by noninvasive tests and treatment of underlying causes are crucial in delaying disease progression. Prevention through vaccination, lifestyle change, and alcohol abstinence are key in preventing incidence. Novel therapies like antifibrotic agents, gene editing technologies, stem cell therapy, and artificial liver assist systems hold promise for the reversal of disease and enhanced survival, marking the turn toward regenerative and personalized medicine in the management of cirrhosis

Liver cirrhosis; hepatic fibrosis; portal hypertension; hepatic encephalopathy; ascites; hepatocellular carcinoma; nonalcoholic fatty liver disease; viral hepatitis; antifibrotic treatment; liver transplantation; stem cell therapy; prognosis; prevention.

"A COMPREHENSIVE REVIEW ON LIVER CIRRHOSIS: PATHOGENESIS, DIAGNOSIS,AND MANAGEMENT", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.12, Issue 11, page no.a27-a36, November-2025, Available :http://www.jetir.org/papers/JETIR2511004.pdf

"A COMPREHENSIVE REVIEW ON LIVER CIRRHOSIS: PATHOGENESIS, DIAGNOSIS,AND MANAGEMENT", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.12, Issue 11, page no. ppa27-a36, November-2025, Available at : http://www.jetir.org/papers/JETIR2511004.pdf