UGC Approved Journal no 63975(19)

ISSN: 2349-5162 | ESTD Year : 2014
Call for Paper
Volume 11 | Issue 10 | October 2024

JETIREXPLORE- Search Thousands of research papers



WhatsApp Contact
Click Here

Published in:

Volume 10 Issue 4
April-2023
eISSN: 2349-5162

UGC and ISSN approved 7.95 impact factor UGC Approved Journal no 63975

7.95 impact factor calculated by Google scholar

Unique Identifier

Published Paper ID:
JETIRFW06041


Registration ID:
512327

Page Number

315-327

Share This Article


Jetir RMS

Title

Development and Validation of a Stability Indicating HPTLC Method for the Determination of Prucalopride succinate in Bulk and Tablet dosage form

Abstract

A simple, precise, and accurate stability-indicating high-performance thin layer chromatographic method for analysis of Prucalopride succinate It has been demonstrated and proven that in the presence of its degradation products. Optimum separation among Prucalopride succinate and the results of its degradation was achieved by use of silica gel 60F254 as stationary phase with Toluene: Methanol: Glacial acetic acid (7:2.5:0.5 v/v/v) as a mobile phase. Densitometric quantification was performed at 240 nm. The retention factor was revealed to be 0.25 ± 0.10for parent drug. The drug was subjected to different stress conditions like acid, base hydrolysis, oxidation, thermal degradation and photolysis. In accordance with ICH Q2 (R1) guidelines, the approach was successfully validated. The method exhibited an adequate linearity (r =0.995), selectivity, precision and accuracy. Prucalopride succinate in bulk and pharmaceutical dose form can be routinely analysed using the developed method.

Key Words

Prucalopride succinate, Stability indicating method, ICH, HPTLC, Validation.

Cite This Article

"Development and Validation of a Stability Indicating HPTLC Method for the Determination of Prucalopride succinate in Bulk and Tablet dosage form", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.10, Issue 4, page no.315-327, April-2023, Available :http://www.jetir.org/papers/JETIRFW06041.pdf

ISSN


2349-5162 | Impact Factor 7.95 Calculate by Google Scholar

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 7.95 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Cite This Article

"Development and Validation of a Stability Indicating HPTLC Method for the Determination of Prucalopride succinate in Bulk and Tablet dosage form", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.10, Issue 4, page no. pp315-327, April-2023, Available at : http://www.jetir.org/papers/JETIRFW06041.pdf

Publication Details

Published Paper ID: JETIRFW06041
Registration ID: 512327
Published In: Volume 10 | Issue 4 | Year April-2023
DOI (Digital Object Identifier):
Page No: 315-327
Country: -, -, India .
Area: Engineering
ISSN Number: 2349-5162
Publisher: IJ Publication


Preview This Article


Downlaod

Click here for Article Preview

Download PDF

Downloads

000186

Print This Page

Current Call For Paper

Jetir RMS